Plasma Protein Therapy for ED
A non-surgical, drug-free treatment for erectile dysfunction that uses plasma from your own blood, rich in growth factors and healing proteins, to support tissue repair and blood flow. It is an off-label regenerative use, offered after a private consultation with one of our providers, and the whole appointment takes about 45 to 60 minutes.
How plasma proteintherapy works
Your blood carries platelets loaded with growth factors, the proteins your body uses to heal and rebuild tissue. In this treatment we draw a small amount of your blood, spin it in a centrifuge to concentrate that plasma, and inject it into targeted areas of the penis after a topical numbing cream takes effect. The aim is regenerative: encouraging new blood vessel formation, supporting nerve and blood vessel repair, and stimulating collagen production in the treated tissue.
That approach is fundamentally different from oral ED medication. Pills work dose by dose; plasma protein therapy addresses the underlying tissue health that erections depend on. Many men report improved firmness, sensitivity, and confidence in the weeks after treatment, with changes developing gradually over two to three months as the tissue responds. Because the material is concentrated from your own blood, the risk of an allergic reaction or rejection is very low.
Honesty matters here: like its use for incontinence, plasma protein therapy is not specifically FDA-approved for erectile dysfunction. It is an off-label regenerative use, and results vary from man to man. Whether you are a candidate, and whether it should stand alone or combine with options like EMSELLA, shockwave therapy, or hormone optimization, is decided at a private, judgment-free consultation.
Who is this treatment for?
For men who want a regenerative, drug-free approach to ED, whether pills have fallen short or simply are not the road they want.
This is an off-label use, and candidacy is individual. We review your health history and the causes behind your ED at a private consultation, and tell you honestly whether plasma protein therapy, EMSELLA, Botox for ED, or a combination is the right plan, or whether your case calls for something else entirely.
Mild to moderate ED
The treatment is best suited to men whose erectile function has declined but not disappeared.
Oral medications have not worked well
Men who respond poorly to pills often look for an approach that works on the tissue itself.
You want a natural, drug-free route
The injected material is concentrated from your own blood, with no pharmaceuticals involved.
Peyronie's disease
Men with penile curvature may be candidates; this is evaluated individually at consultation.
Recovering function after prostate surgery
Regenerative support for nerves and blood vessels can be part of a recovery plan.
Optimizing sexual health
Some men without a clinical ED diagnosis choose this treatment as part of a broader sexual wellness plan.
Whatto expect.
Book a consultationPricing depends on your treatment plan and is discussed privately. The treatment is elective and not typically covered by insurance; flexible payment and financing options are available.
One in-office appointment covers the blood draw, centrifuge separation, topical numbing, and injection.
Return to normal activity the same day. Avoid sexual activity for 24 to 48 hours. Mild swelling or bruising at the injection site resolves quickly.
Improvements often begin within a few weeks and develop fully over two to three months. Benefits can last 12 to 18 months, with occasional booster treatments available for ongoing results.
Frequently asked questions
Is plasma protein therapy FDA-approved for ED?
No. Like other plasma-based therapies, it is not specifically FDA-approved for erectile dysfunction; it is an off-label regenerative use. Your provider explains what that means, what the treatment can and cannot promise, and whether you are a candidate at a private consultation.
Is the treatment painful?
A topical numbing cream is applied before the injection, so most men feel little to no discomfort, typically just a sensation of mild pressure.
How many treatments will I need?
Many men notice improvement after one session, and a series of two to three treatments may be recommended for the best results. Occasional booster treatments help maintain them over time.
How long does the procedure take?
About 45 to 60 minutes in our office, covering the blood draw, plasma preparation, numbing, and injection, with minimal downtime afterward.
Are there any side effects?
Because the treatment uses your own blood, side effects are minimal. Some men have mild swelling or bruising at the injection site, which resolves quickly.
How soon can I resume sexual activity?
We ask that you wait 24 to 48 hours after treatment. Beyond that, you can return to normal activity the same day.
Can it be combined with other treatments?
Yes. It can pair with shockwave therapy, hormone optimization, and other sexual wellness treatments, including EMSELLA for pelvic floor strength. We build the combination around your goals.
Is it covered by insurance?
The treatment is considered elective, so it is not typically covered by insurance. We offer flexible payment and financing options, discussed at your consultation.
Ask about body contouring.
Tell us the area you have in mind and what you have tried. We will come back with which treatments make sense, what they cost, and when you could start.
Your details go straight to our Montgomery Road front desk and are never shared. A team member replies during office hours, usually the same day.
Ready when you are.
Book a consultation at our Montgomery Road office, or call and we will help you decide where to start.
Medically reviewed by Shalini Gupta, MD, Harvard-trained dermatologist and founder of The Dermatology, Laser & Vein Center. Last reviewed September 2026. This page is for education and is not a substitute for a personalized medical consultation.